Depression & Stress

This ongoing study of stress responses reveals phenotypic differences in women with PMDD and those with a history of Major Depressive Disorder. In contrast to the blunted stress responses seen in women with PMDD, those with MDD histories exhibit hyperactivity in the HPA Axis, as seen by heightened baseline levels of Corticotrophin Releasing Hormone (CRH), Cortisol, β-Endorphin and ACTH. These findings suggest that, in women genetically vulnerable to develop MDD, hyperactivity of the stress axes may continue beyond remission of the depressive episode.

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